Engineering a robust DNA split proximity circuit with minimized circuit leakage

Engineering a robust DNA split proximity circuit with minimized circuit leakage

DNA circuit is a versatile and highly-programmable toolbox which can potentially be used for the autonomous sensing of dynamic events, such as biomolecular interactions. However, the experimental implementation of in silico circuit designs has been hindered by the problem of circuit leakage. Here, we systematically analyzed the sources and characteristics of various types of leakage in a split ...

Engineering self-contained DNA circuit for proximity recognition and localized signal amplification of target biomolecules

Biomolecular interactions have important cellular implications, however, a simple method for the sensing of such proximal events is lacking in the current molecular toolbox. We designed a dynamic DNA circuit capable of recognizing targets in close proximity to initiate a pre-programmed signal transduction process resulting in localized signal amplification. The entire circuit was engineered to ...

Circuit Techniques for Leakage Reduction

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Panel Rejects Ninth Circuit Split

Control of Series Resonant Converter with Robust Performance Against Load and Power Circuit Components Uncertainties

Robust performance controller design for duty-cycle controlled series resonant converter (SRC) is proposed in this paper. The uncertainties of the converter are analyzed with load variation and power circuit components tolerances are taken into consideration. Additionally, a nominal performance (NP) controller is designed. Closed-loop system is simulated with Orcad and simulation results of r...